Interactive Manhattan plots showing LabWAS Meta-analysis results in BioVU and MGBB, with one primary and four conditional LabWAS models. Each triangle represents association with a single lab test (a total of 123 matched across both sites), with system categories shown on the x-axis and -log10(p) shown on the y-axis. The direction of the triangles indicates the direction of effects. The grey solid line indicates Bonferroni-corrected significance threshold α = 0.05/(123*6) = 6.78e-5 and the grey dotted line indicates α = 0.05.
Mouseover data points to see the corresponding phecode, beta and p values. Select areas to zoom in. Click on reset axes to return to the original figure.
cov0: primary LabWAS model adjusting for baseline covariates;
Psyc-specific: additionally controlling for factor-specific diagnoses;
Psyc-general: additionally controlling for factor-general diagnoses;
Psyc+TUD: additionally controlling for factor-general diagnoses and Tobacco use disorder;
Psyc+TUD+BMI: additionally controlling for factor-general diagnoses, Tobacco use disorder, and median body mass index
See Methods of the original paper for more information.